Endocrine Abstracts

A 36 years of old patient was admitted to the intensive care unit of cardiology when he experienced palpitations and orthopnea. The patient’s complaints started about 2 years ago as syncope and sudden shortness of breath. Thorax CT showed pleural effusion and increased cardiothoracic index. Findings on ECHO were : Ejection fraction 35%, severe mitral regurgitation and global hypokinesia. Coronary angiogram showed a fibrocalcific plaque noted in in the distal LAD. The pati...

Background: Treatment for advanced adrenocortical carcinoma (ACC) consists of mitotane alone or combined with etoposide, doxorubicin and cisplatin (EDP), yet their efficacy is limited and burdened with significant toxicity. Moreover, markers of response are lacking. Inflammation-based scores have been proposed as prognostic factors in several malignancies including ACC, and recently also as predictors of gemcitabine+capecitabine efficacy, second-line treatment in progressive d...

Von Hippel-Lindau (VHL) syndrome is a pathological condition that causes various clinical symptoms and is difficult to diagnose. The most common pathological lesions are hemangioblastomas of the central nervous system, retinal angiomas, renal clear cell carcinomas, and pheochromocytomas. Here we reposrt a case of likely to be VHL due to his family history.Case: A 33-year-old male suffering from hypertension and a history of hemangioblastoma operated in 2...

Background: Micro vascular complications are the major outcome of Type 2 Diabetes Mellitus progression, which reduces the quality of life and increases diabetic morbidity & mortality. As the incidence of type 2 diabetes is growing day by day; our search for its aetiology and pathogenesis is also ever growing to predict its risk factors and early screening for better care and prevention of its complications. Many studies have tried to link susceptibility of type 2 diabetes ...

Introduction: Recently, it has been suggested that thyrotropin (TSH) concentration can be used as a marker for prediction of thyroid malignancy. However, the association between the cytology results and TSH levels is not clear. In this study, we aimed to investigate the relationship between TSH levels and Bethesda categories and determine the role of TSH levels in prediction of malignancy in patients with different Bethesda categories.Methods: The data o...

Background: We aimed to evaluate malignancy rate in thyroid nodules ≥4 cm and determine false negativity of fine needle aspiration biopsy (FNAB) in these nodules.Methods: Patients who underwent thyroidectomy between January 2007 and December 2014 in our institution were reviewed. Demographical and clinical data and preoperative ultrasonography (US) findings were obtained from the medical records. The nodules in these patients were grouped as &#8805...

Introduction: In this study, we aimed to evaluate impact of multifocality, tumor number and total tumor diameter on clinicopathological features of PTC.Methods: Medical records of 912 patients who underwent thyroidectomy and diagnosed with PTC were reviewed retrospectively. Patients were grouped into 4 according to number of tumoral foci; N1 (1 focus), N2 (2 foci), N3 (3 foci) and N4 (≥ 4 foci). The diameter of the largest tumor was considered as t...

Introduction: In this study, we aimed to evaluate the usefulness of ratio of primary tumor diameter to total tumor diameter as a new parameter for the differentiation of agressive and favorable papillary thyroid microcarcinomas (PTMC).Methods: The diameter of the largest tumor focus was taken as the primary tumour diameter (PTD). For multifocal tumors, total tumor diameter (TTD) was calculated as the sum of the maximal diameter of each lesion. A ratio wa...

Background: Lack of expression of MGMT (O-6-methylguanine-DNA methyltransferase) is associated with a better tumour response to temozolomide. There are no systematic studies of MGMT expression in pituitary tumour series.Aim: We introduced MGMT immunohistochemistry for all pituitary adenoma specimens in 2011. In this study we investigated the immunohistochemical expression of MGMT in a large series of pituitary adenomas, in order to determine (1) the over...

Introduction: Primary hyperparathyroidism (PHP) is a highly prevalent disease, which is treated most effectively by surgery. Postoperative hypocalcaemia, a morbidity of surgical treatment of parathyroidism, can prolong the hospital stay. The aim of this study was to identify the factors predictive of hypocalcaemia and hungry bone syndrome (HBS) in patients who undergo parathyroidectomy due to PHP.Materials and methods: Preoperatively and on days 1 and 4,...